Activation of Targeted Necrosis by a p53 Peptide
نویسندگان
چکیده
منابع مشابه
Mutant p53 Enhances Nuclear Factor KB Activation by Tumor Necrosis Factor A in Cancer Cells
Mutations in the p53 tumor suppressor are very frequent in human cancer. Often, such mutations lead to the constitutive overproduction of mutant p53 proteins, which may exert a cancer-promoting gain of function. We now report that cancer-associated mutant p53 can augment the induction of nuclear factor KB (NFKB) transcriptional activity in response to the cytokine tumor necrosis factor A (TNFA)...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m701864200